Liposomal structure: A comparative study on light scattering and chromatography techniques

Liposomes play an important role in medical and pharmaceutical science as, nanoscale drug carriers. One of the most important features is their size and size distribution, influencing both their bio-distribution and their targeting efficiency to tumors and also therapeutic activity of liposomal anti...

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Bibliographic Details
Published in:Journal of dispersion science and technology 2017-11, Vol.38 (11), p.1633-1639
Main Authors: Maherani, Behnoush, Wattraint, Olivier
Format: Article
Language:English
Subjects:
AF4
Anticancer properties
Comparative studies
Drug carriers
Drugs
Fractionation
Life Sciences
Light scattering
light scattering technique
Liposomes
molecular interaction
Molecular interactions
Molecular structure
nanoliposome
Particle size distribution
Photon correlation spectroscopy
Shape effects
ρ values
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Summary:Liposomes play an important role in medical and pharmaceutical science as, nanoscale drug carriers. One of the most important features is their size and size distribution, influencing both their bio-distribution and their targeting efficiency to tumors and also therapeutic activity of liposomal antitumor drugs. In this study, the effect of preparation method and molecular interaction on size and shape of liposome was studied. The size and shape characterization of liposomes was performed by asymmetrical flow field-flow fractionation coupled online with multi-angle light scattering (AF4-MALS). The size distributions obtained by AF4-MALS were compared to mean particle sizes and size distribution measured with other standard method such as Photon Correlation Spectroscopy (PCS). Furthermore, the effect of molecular interaction (hydrophilic and hydrophobic model drugs) on liposomal structure was assessed.
ISSN:0193-2691
1532-2351
DOI:10.1080/01932691.2016.1269651