Proteasomes and transplantology: Current state of the problem and the search for promising trends

Basic research of the structure and functions of multiple forms of proteasomes is overviewed. The proteasomes of liver, acting as a primary lymphoid organ in embryogenesis, displaying nonspecific local immunity, and providing development of tolerance to food and other foreign antigens during the lif...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2017-05, Vol.44 (3), p.237-244
Main Authors: Karpova, Ya. D., Bozhok, G. A., Alabedal’karim, N. M., Lyupina, Yu. V., Astakhova, T. M., Legach, E. I., Sharova, N. P.
Format: Article
Language:English
Subjects:
Antigens
Biochemistry
Biomedical and Life Sciences
Cell Biology
Ecology
Embryogenesis
Immunological tolerance
Life Sciences
Life span
Liver transplantation
Proteasomes
Zoology
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Summary:Basic research of the structure and functions of multiple forms of proteasomes is overviewed. The proteasomes of liver, acting as a primary lymphoid organ in embryogenesis, displaying nonspecific local immunity, and providing development of tolerance to food and other foreign antigens during the lifespan, are described. The role of individual forms of liver proteasomes in transplantology is considered as well as their utility as markers for endocrine transplant survival.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359017030049