Pentapeptide analogs of somatostatin containing a thiazolidine fragment: synthesis and cytotoxic activity

Pentapeptide analogs of somatostatin containing an ( R )-1,3-thiazolidine fragment (Thz) of the general formula X—Thz—Phe—D-Trp—Lys(Y)—Thr—Z were synthesized for the first time. The synthesized compounds were tested for cytotoxic activity against three cancer cell lines (MCF-7, PC3, and HCT-116) and...

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Bibliographic Details
Published in:Russian chemical bulletin 2016-12, Vol.65 (12), p.2948-2951
Main Authors: Balaev, A. N., Osipov, V. N., Okhmanovich, K. A., Ruchko, E. A., Baryshnikova, M. A., Khachatryan, D. S.
Format: Article
Language:English
Subjects:
Analogs
Biomedical materials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cytotoxicity
Fibroblasts
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Inorganic Chemistry
Organic Chemistry
Surgical implants
Synthesis
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Summary:Pentapeptide analogs of somatostatin containing an ( R )-1,3-thiazolidine fragment (Thz) of the general formula X—Thz—Phe—D-Trp—Lys(Y)—Thr—Z were synthesized for the first time. The synthesized compounds were tested for cytotoxic activity against three cancer cell lines (MCF-7, PC3, and HCT-116) and against human embryo fibroblasts.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-016-1683-6