Surface treatment and biomimetic mineralization of porous microspheres fabricated by calcium gluconate-g-poly(D,L-lactide)

Porous hybrid microspheres were fabricated by the synthesized calcium gluconate- g -poly(D,L-lactide) (CG- g -PDLLA) composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the...

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Bibliographic Details
Published in:Chinese journal of polymer science 2017-07, Vol.35 (7), p.837-845
Main Authors: Song, Le-yuan, Jiang, Ni, Gan, Zhi-hua
Format: Article
Language:English
Subjects:
Apatite
Biocompatibility
Biomedical materials
Biomimetics
Calcium
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Crystal structure
Hydroxyapatite
In vitro methods and tests
Industrial Chemistry/Chemical Engineering
Microspheres
Mineralization
Polymer Sciences
Surface treatment
Surgical implants
Tissue engineering
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Summary:Porous hybrid microspheres were fabricated by the synthesized calcium gluconate- g -poly(D,L-lactide) (CG- g -PDLLA) composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. The microspheres were then incubated in a supersaturated simulated body fluid (1.5 SBF) solution for different time to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface are influenced by the induced carboxylate groups and the remained CG. The hybrid CG- g -PDLLA microspheres have the potential as a novel alternative in bone tissue engineering.
ISSN:0256-7679
1439-6203
DOI:10.1007/s10118-017-1940-7