Retinoic acid pre-treatment down regulates V. cholerae outer membrane vesicles induced acute inflammation and enhances mucosal immunity

Highlights • Cholera pentavalent outer membrane vesicles (CPMVs) induce protective immune response after two doses of oral immunization in mice model. • CPMVs induced TLR2 mediated pro-inflammatory cytokines and acute inflammation in vitro and in vivo. • Pre-treatment of All-trans retinoid acid (ATR...

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Bibliographic Details
Published in:Vaccine 2017-06, Vol.35 (28), p.3534-3547
Main Authors: Sinha, Ritam, Howlader, Debaki Ranjan, Ta, Atri, Mitra, Soma, Das, Santasabuj, Koley, Hemanta
Format: Article
Language:English
Subjects:
Adaptive immunity
Administration, Oral
Allergy and Immunology
Animals
Animals, Newborn
Antibodies, Bacterial - blood
Antigens
ATRA
Bacteria
Bacterial Outer Membrane Proteins - immunology
Bacterial Outer Membrane Proteins - toxicity
Bacterial vesicles
Children
Cholera
Cholera - immunology
Cholera - prevention & control
Cholera Vaccines - administration & dosage
Cholera Vaccines - immunology
Cholera Vaccines - toxicity
CPMVs
Cytokines - biosynthesis
Developing countries
Disease Models, Animal
Effectiveness
Female
Immune response
Immune system
Immunity
Immunity, Mucosal
Immunization
Immunogenicity, Vaccine
Immunoglobulin G - blood
Inflammation
Inflammation - prevention & control
LDCs
Malnutrition
Membrane vesicles
Membranes
Men
Metabolites
Mice
Mice, Inbred BALB C
Mucosal immunity
OMVs
Oral cavity
Pathogens
Retinoic acid
Rodents
TLR2
TLR2 protein
Toll-Like Receptor 2 - immunology
Toll-like receptors
Toxicity
Tretinoin - administration & dosage
Tretinoin - immunology
Tretinoin - pharmacology
Vaccines
Vesicles
Vibrio cholerae - immunology
Vitamin A
Waterborne diseases
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Description
Summary:Highlights • Cholera pentavalent outer membrane vesicles (CPMVs) induce protective immune response after two doses of oral immunization in mice model. • CPMVs induced TLR2 mediated pro-inflammatory cytokines and acute inflammation in vitro and in vivo. • Pre-treatment of All-trans retinoid acid (ATRA) significantly reduces CPMVs induced TLR2 mediated pro-inflammatory cytokine response in vitro and in vivo. • Pre-treatment of ATRA induces mucosal as well as protective immune response but not systemic immune response after two doses of oral immunization with CPMVs.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.05.036