Use of high-performance liquid chromatography coupled with high-resolution mass spectrometry for the identification and quantitative determination of tetrodotoxin in pharmaceuticals

A procedure is developed for the identification and determination of tetrodotoxin in pharmaceuticals by liquid chromatography coupled with high resolution mass spectrometry ( HPLC−HRMS ). The components of a pharmaceutical sample were separated in the gradient elution mode on a HILIC hydrophilic sor...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2017-06, Vol.72 (6), p.632-638
Main Authors: Shalabai, V. V., Taranchenko, V. F., Rybal’chenko, I. V., Aksenov, A. V., Antokhin, A. M., Semchenko, F. M., Krymchak, M. S.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Calibration
Chemistry
Chemistry and Materials Science
Chromatography
Correlation
Elution
High performance liquid chromatography
High resolution
Ionization
Liquid chromatography
Mass spectrometry
Pharmaceuticals
Scientific imaging
Tetrodotoxin
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Summary:A procedure is developed for the identification and determination of tetrodotoxin in pharmaceuticals by liquid chromatography coupled with high resolution mass spectrometry ( HPLC−HRMS ). The components of a pharmaceutical sample were separated in the gradient elution mode on a HILIC hydrophilic sorbent and detected by HRMS with electrospray ionization in the mode of registration of selected ion transitions. The calibration curve is linear in the range 0.75−1.25 μg/mL with the correlation coefficient > 0.9995.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934817060144