Cancer Diagnosis: Nanoelectromechanical Chip (NELMEC) Combination of Nanoelectronics and Microfluidics to Diagnose Epithelial and Mesenchymal Circulating Tumor Cells from Leukocytes (Small 7/2016)

An integrated nano‐electromechanical chip (NELMEC) is developed for the label‐free diagnosis of both epithelial and mesenchymal circulating tumor cells by M. Abdolahad and co‐workers. Large single cells (>12 micrometers) are trapped at the opening of analysis microchannel arrays. On page 883, the...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-02, Vol.12 (7), p.882-882
Main Authors: Hosseini, Seied Ali, Abdolahad, Mohammad, Zanganeh, Somayeh, Dahmardeh, Mahyar, Gharooni, Milad, Abiri, Hamed, Alikhani, Alireza, Mohajerzadeh, Shams, Mashinchian, Omid
Format: Article
Language:English
Subjects:
Arrays
biological materials
Cancer
cancer diagnosis
cancer drugs
Capacitance
cells
Channels
Diagnosis
Diagnostic systems
Electrodes
Indication
Leukocytes
membranes
Microfluidics
Micrometers
Nanoelectronics
Nanotechnology
Silicon
tumors
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Summary:An integrated nano‐electromechanical chip (NELMEC) is developed for the label‐free diagnosis of both epithelial and mesenchymal circulating tumor cells by M. Abdolahad and co‐workers. Large single cells (>12 micrometers) are trapped at the opening of analysis microchannel arrays. On page 883, there is an observable difference between the membrane capacitance of ECTCs and MCTCs from WBCs, as measured by silicon nanograss electrodes patterned at the entrance of the channels. This is the key indication in diagnostic approaches of NELMEC with unprocessed blood.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201670033