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Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells
We describe herein a Toll‐like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK‐BR‐3 breast carcinoma cells. Our results show that poly(I:...
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| Published in: | Chemistry : a European journal 2016-01, Vol.22 (5), p.1582-1586 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 1586 |
| container_issue | 5 |
| container_start_page | 1582 |
| container_title | Chemistry : a European journal |
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| creator | Ultimo, Amelia Giménez, Cristina Bartovsky, Pavel Aznar, Elena Sancenón, Félix Marcos, M. Dolores Amorós, Pedro Bernardo, Ana R. Martínez-Máñez, Ramón Jiménez-Lara, Ana M. Murguía, José R. |
| description | We describe herein a Toll‐like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK‐BR‐3 breast carcinoma cells. Our results show that poly(I:C)‐conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA–TLR3 interaction. Such interaction also triggered apoptotic pathways in SK‐BR‐3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles′ mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
Messenger of death: A new drug‐delivery system based in mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for targeting breast carcinoma cells is reported (see figure). |
| doi_str_mv | 10.1002/chem.201504629 |
| format | article |
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Messenger of death: A new drug‐delivery system based in mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for targeting breast carcinoma cells is reported (see figure).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201504629</identifier><identifier>PMID: 26641630</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Antibiotics ; Anticancer properties ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Antitumor activity ; antitumor agents ; Apoptosis ; Breast cancer ; Breast carcinoma ; Breast Neoplasms - chemistry ; Breast Neoplasms - drug therapy ; Cancer ; Capping ; Cargo ; Cell Line, Tumor ; Chemistry ; Cytotoxicity ; Double-stranded RNA ; Doxorubicin ; Doxorubicin - chemistry ; drug delivery ; Female ; Humans ; Immunity ; Immunity, Innate ; mesoporous gated materials ; Nanoparticles ; Nanoparticles - chemistry ; Ovarian cancer ; Poly I-C - chemistry ; Poly I-C - pharmacology ; Polyinosinic:polycytidylic acid ; Ribonucleic acid ; RNA ; RNA, Double-Stranded - chemistry ; RNA, Double-Stranded - pharmacology ; Silica ; Silicon dioxide ; Silicon Dioxide - chemistry ; TLR3 protein ; Toll-like receptors ; Viability</subject><ispartof>Chemistry : a European journal, 2016-01, Vol.22 (5), p.1582-1586</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5539-87acbb029482cf6bd5f7037d0b75f1e9df30fd7a9c04ff46aa3992b569aa8a003</citedby><cites>FETCH-LOGICAL-c5539-87acbb029482cf6bd5f7037d0b75f1e9df30fd7a9c04ff46aa3992b569aa8a003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26641630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ultimo, Amelia</creatorcontrib><creatorcontrib>Giménez, Cristina</creatorcontrib><creatorcontrib>Bartovsky, Pavel</creatorcontrib><creatorcontrib>Aznar, Elena</creatorcontrib><creatorcontrib>Sancenón, Félix</creatorcontrib><creatorcontrib>Marcos, M. Dolores</creatorcontrib><creatorcontrib>Amorós, Pedro</creatorcontrib><creatorcontrib>Bernardo, Ana R.</creatorcontrib><creatorcontrib>Martínez-Máñez, Ramón</creatorcontrib><creatorcontrib>Jiménez-Lara, Ana M.</creatorcontrib><creatorcontrib>Murguía, José R.</creatorcontrib><title>Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells</title><title>Chemistry : a European journal</title><addtitle>Chem. Eur. J</addtitle><description>We describe herein a Toll‐like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK‐BR‐3 breast carcinoma cells. Our results show that poly(I:C)‐conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA–TLR3 interaction. Such interaction also triggered apoptotic pathways in SK‐BR‐3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles′ mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
Messenger of death: A new drug‐delivery system based in mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for targeting breast carcinoma cells is reported (see figure).</description><subject>Antibiotics</subject><subject>Anticancer properties</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitumor activity</subject><subject>antitumor agents</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Breast carcinoma</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cancer</subject><subject>Capping</subject><subject>Cargo</subject><subject>Cell Line, Tumor</subject><subject>Chemistry</subject><subject>Cytotoxicity</subject><subject>Double-stranded RNA</subject><subject>Doxorubicin</subject><subject>Doxorubicin - chemistry</subject><subject>drug delivery</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunity, Innate</subject><subject>mesoporous gated materials</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Ovarian cancer</subject><subject>Poly I-C - chemistry</subject><subject>Poly I-C - pharmacology</subject><subject>Polyinosinic:polycytidylic acid</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Double-Stranded - chemistry</subject><subject>RNA, Double-Stranded - pharmacology</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>TLR3 protein</subject><subject>Toll-like receptors</subject><subject>Viability</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc9v0zAYhiMEYmVw5YgscU75HMd2fCxR2Spt5VcRiIvlOHaXktid7Wj0yH9Opo6KE5z8SX7e59OnN8teYphjgOKNvjHDvABMoWSFeJTNMC1wTjijj7MZiJLnjBJxlj2LcQcAghHyNDsrGCsxIzDLfm1U2JrUuS1aOaeSQathGF2XDuiuSzeojZ_Wi7z2bjdup98WXZvo9z74MaLPXd9phdbK-b0KqdO9iehD8INP07BwqUvj4ANaWmt0isg79DYYFROqldMmoNr0fXyePbGqj-bFw3uefXm33NSX-dX7i1W9uMo1nS7IK65000AhyqrQljUttRwIb6Hh1GIjWkvAtlwJDaW1JVOKCFE0lAmlKgVAzrPXR-8--NvRxCR3fgxuWimxAF5UmID4J8VphQFDiSdqfqR08DEGY-U-dIMKB4lB3vci73uRp16mwKsH7dgMpj3hf4qYAHEE7rreHP6jk_Xl8vpveX7MdjGZn6esCj8k44RT-XV9Ib9_23ysOSZyTX4Dqr6p_A</recordid><startdate>20160126</startdate><enddate>20160126</enddate><creator>Ultimo, Amelia</creator><creator>Giménez, Cristina</creator><creator>Bartovsky, Pavel</creator><creator>Aznar, Elena</creator><creator>Sancenón, Félix</creator><creator>Marcos, M. Dolores</creator><creator>Amorós, Pedro</creator><creator>Bernardo, Ana R.</creator><creator>Martínez-Máñez, Ramón</creator><creator>Jiménez-Lara, Ana M.</creator><creator>Murguía, José R.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope></search><sort><creationdate>20160126</creationdate><title>Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells</title><author>Ultimo, Amelia ; Giménez, Cristina ; Bartovsky, Pavel ; Aznar, Elena ; Sancenón, Félix ; Marcos, M. 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Dolores</au><au>Amorós, Pedro</au><au>Bernardo, Ana R.</au><au>Martínez-Máñez, Ramón</au><au>Jiménez-Lara, Ana M.</au><au>Murguía, José R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chem. Eur. J</addtitle><date>2016-01-26</date><risdate>2016</risdate><volume>22</volume><issue>5</issue><spage>1582</spage><epage>1586</epage><pages>1582-1586</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><coden>CEUJED</coden><abstract>We describe herein a Toll‐like receptor 3 (TLR3) targeting delivery system based on mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for controlled cargo delivery in SK‐BR‐3 breast carcinoma cells. Our results show that poly(I:C)‐conjugated nanoparticles efficiently targeted breast cancer cells due to dsRNA–TLR3 interaction. Such interaction also triggered apoptotic pathways in SK‐BR‐3, significantly decreasing cells viability. Poly(I:C) cytotoxic effect in breast carcinoma cells was enhanced by loading nanoparticles′ mesopores with the anthracyclinic antibiotic doxorubicin, a commonly used chemotherapeutic agent.
Messenger of death: A new drug‐delivery system based in mesoporous silica nanoparticles capped with the synthetic double stranded RNA polyinosinic–polycytidylic acid (poly(I:C)) for targeting breast carcinoma cells is reported (see figure).</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26641630</pmid><doi>10.1002/chem.201504629</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibiotics Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity antitumor agents Apoptosis Breast cancer Breast carcinoma Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Cancer Capping Cargo Cell Line, Tumor Chemistry Cytotoxicity Double-stranded RNA Doxorubicin Doxorubicin - chemistry drug delivery Female Humans Immunity Immunity, Innate mesoporous gated materials Nanoparticles Nanoparticles - chemistry Ovarian cancer Poly I-C - chemistry Poly I-C - pharmacology Polyinosinic:polycytidylic acid Ribonucleic acid RNA RNA, Double-Stranded - chemistry RNA, Double-Stranded - pharmacology Silica Silicon dioxide Silicon Dioxide - chemistry TLR3 protein Toll-like receptors Viability |
| title | Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells |
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