Proliferation of cultured glioma cells mediated by coenzyme Q10 under conditions of serum deprivation

The effect of coenzyme Q 10 on glioma-cell proliferation under serum-deprived conditions has been studied. Our results have shown that the addition of coenzyme Q 10 into a serum-free culture medium enhances cell viability, stimulates cell growth, restores mitochondrial potential, and increases the q...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue biology 2017-05, Vol.11 (3), p.220-226
Main Authors: Krylova, N. G., Kulahava, T. A., Koran, S. V., Semenkova, G. N.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Brain tumors
Cell Biology
Cell culture
Cell growth
Cell proliferation
Coenzyme Q10
Extracellular signal-regulated kinase
Glioma cells
Glutathione
Kinases
Life Sciences
Mitochondria
Protein kinase C
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effect of coenzyme Q 10 on glioma-cell proliferation under serum-deprived conditions has been studied. Our results have shown that the addition of coenzyme Q 10 into a serum-free culture medium enhances cell viability, stimulates cell growth, restores mitochondrial potential, and increases the quantity of energized mitochondria. It is found that coenzyme Q 10 -induced glioma-cell proliferation in conditions of serum deficiency is a result of an intracellular reduced glutathione concentration with subsequent activation of protein kinase C, ERK1/2, and phosphoinositol-3-kinase.
ISSN:1990-519X
1990-5203
DOI:10.1134/S1990519X17030063