Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax

Introduction: Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalas...

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Bibliographic Details
Published in:Human & experimental toxicology 2017-07, Vol.36 (7), p.663-669
Main Authors: Karadas, S, Aslan, M, Ceylan, MR, Sunnetcioglu, M, Bozan, N, Kara, H, Demir, H
Format: Article
Language:English
Subjects:
Adult
Anthrax
Anthrax - blood
Aryldialkylphosphatase - blood
Arylesterase
Bacteria
Carboxylic Ester Hydrolases - blood
Catalase
Catalase - blood
Cholesterol - blood
Female
Health risk assessment
Humans
Male
Malondialdehyde
Malondialdehyde - blood
Middle Aged
Military air strikes
Oxidative Stress
Paraoxonase
Paraoxonase 1
Pathogenesis
Patients
Skin Diseases, Bacterial - blood
Superoxide dismutase
Superoxide Dismutase - blood
Triglycerides - blood
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Summary:Introduction: Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) levels in patients with cutaneous anthrax. Materials and methods: Fifteen patients with cutaneous anthrax and 15 healthy controls were enrolled in this study. The serum MDA levels, SOD levels, paraoxonase, arylesterase, and catalase activities were measured using a spectrophotometer. Results: The serum SOD levels, paraoxonase, arylesterase, and catalase activities were significantly lower in patients with cutaneous anthrax than in controls (for all, p < 0.001), whereas MDA levels were significantly higher (p < 0.001). No significant correlation was found between serum paraoxonase activity, arylesterase activity, SOD levels, and MDA levels (all, p > 0.05) in patients with cutaneous anthrax. Conclusions: The current study was the first to show decreased antioxidant levels and increased oxidant levels in patients with cutaneous anthrax. Therefore, decreased PON1 activity may play a role in the pathogenesis of cutaneous anthrax.
ISSN:0960-3271
1477-0903
DOI:10.1177/0960327116661020