The Neurotropic, Anti-Inflammatory, and Antitumor Properties of the Hopantenic Acid Molecule Based on Chemoinformatic Analysis

Hopantenic acid is a known nootropic agent with a chemical structure close to that of pantothenic acid (vitamin B5). The neurotropic effect of hopantenic acid may occur as a result of binding with δ and κ opioid receptors, modulating acetylcholine secretion, and interacting with dopamine receptors....

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2016-11, Vol.46 (9), p.1097-1106
Main Authors: Gromova, O. A., Torshin, I. Yu, Limanova, O. A., Gromov, A. N., Fedotova, L. E., Rudakov, K. V.
Format: Article
Language:English
Subjects:
Acetylcholine
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Dopamine receptors
Inflammation
Metabolism
Neurobiology
Neurosciences
Opioid receptors (type kappa)
Pantothenic acid
Prostaglandins
Steroid hormones
Steroids
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Summary:Hopantenic acid is a known nootropic agent with a chemical structure close to that of pantothenic acid (vitamin B5). The neurotropic effect of hopantenic acid may occur as a result of binding with δ and κ opioid receptors, modulating acetylcholine secretion, and interacting with dopamine receptors. Apart from the neurotropic effects, hopantenic acid can modulate the metabolism of prostaglandins and steroids, and may have antitumor actions.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-016-0357-z