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Perioperative chemotherapy versus neoadjuvant chemoradiotherapy for esophageal or GEJ adenocarcinoma: A propensity score‐matched analysis comparing toxicity, pathologic outcome, and survival

Objectives To evaluate toxicity, pathologic outcome, and survival after perioperative chemotherapy (pCT) compared to neoadjuvant chemoradiotherapy (nCRT) followed by surgery for patients with resectable esophageal or gastroesophageal junction (GEJ) adenocarcinoma. Methods Consecutive patients with r...

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Bibliographic Details
Published in:Journal of surgical oncology 2017-06, Vol.115 (7), p.812-820
Main Authors: Goense, Lucas, van der Sluis, Pieter C., van Rossum, Peter S. N., van der Horst, Sylvia, Meijer, Gert J., Haj Mohammad, Nadia, van Vulpen, Marco, Mook, Stella, Ruurda, Jelle P., van Hillegersberg, Richard
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Language:English
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Summary:Objectives To evaluate toxicity, pathologic outcome, and survival after perioperative chemotherapy (pCT) compared to neoadjuvant chemoradiotherapy (nCRT) followed by surgery for patients with resectable esophageal or gastroesophageal junction (GEJ) adenocarcinoma. Methods Consecutive patients with resectable esophageal or GEJ adenocarcinoma who underwent pCT (epirubicin, cisplatin, and capecitabine) or nCRT (paclitaxel, carboplatin, and 41.4 Gy) followed by surgery in a tertiary referral center in the Netherlands were compared. Propensity score matching was applied to create comparable groups. Results Of 193 eligible patients, 21 were discarded after propensity score matching; 86 and 86 patients who underwent pCT and nCRT, respectively, remained. Grade ≥3 thromboembolic events occurred only in the pCT group (19% vs. 0%, P 
ISSN:0022-4790
1096-9098
DOI:10.1002/jso.24596