Iron‐Catalyzed Anti‐Markovnikov Hydroamination of Vinylpyridines

An efficient, green and atom‐economical iron‐catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C fo...

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Published in:Asian journal of organic chemistry 2017-06, Vol.6 (6), p.694-697
Main Authors: Peng, Yahui, Qin, Cong, Chen, Xiaobei, Li, Jianjun, Li, Hao, Wang, Wei
Format: Article
Language:English
Subjects:
anti-Markovnikov
azoles
Economics
Heterocyclic compounds
hydroamination
Iron
Organic chemistry
Toluene
Triazoles
vinylpyridines
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description An efficient, green and atom‐economical iron‐catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol % FeCl3 in toluene at 110 °C for 3 h to afford the anti‐Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities. Oh, the IRONy! An efficient, green and atom‐economical iron‐catalyzed strategy for the hydroamination of vinylpyridines with azoles has been developed. The reaction affords only anti‐Markovnikov hydroamination products in moderate to excellent yields.
doi_str_mv 10.1002/ajoc.201700072
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subjects anti-Markovnikov
azoles
Economics
Heterocyclic compounds
hydroamination
Iron
Organic chemistry
Toluene
Triazoles
vinylpyridines
title Iron‐Catalyzed Anti‐Markovnikov Hydroamination of Vinylpyridines
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