Microwave-assisted synthesis, molecular docking, and biological evaluation of 2-arylidene-2H-furo[2,3-f]chromen-3(7H)-ones as antioxidant and antimicrobial agents

An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2 H -furo[2,3- f ]chromen-3(7 H )-ones 6a–j in excellent yields was described and structural assignment of the products was confirmed on the basis of IR, 1 H NMR, 13 C NMR, MS, and analytical data. The synthesized compound...

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Bibliographic Details
Published in:Medicinal chemistry research 2017-08, Vol.26 (8), p.1735-1746
Main Authors: Ashok, Dongamanti, Rangu, Kavitha, Gundu, Srinivas, Lakkadi, Arunapriya, Tigulla, Parthasarathy
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Antioxidants
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chemical synthesis
Hydrogen peroxide
Iridium
Mathematical analysis
Molecular docking
NMR
Nuclear magnetic resonance
Original Research
Pharmacology/Toxicology
Prostaglandin endoperoxide synthase
Radicals
Scavenging
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Summary:An efficient microwave-assisted method of synthesis of some novel 2-arylidene-2 H -furo[2,3- f ]chromen-3(7 H )-ones 6a–j in excellent yields was described and structural assignment of the products was confirmed on the basis of IR, 1 H NMR, 13 C NMR, MS, and analytical data. The synthesized compounds were screened for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide radicals. The compounds 5d , 5h , 6a , 6e , and 6j exhibited better radical scavenging ability. Antimicrobial activity results demonstrated that compounds 5b , 5e , 6b , 6c , and 6e showed promising antimicrobial potency. The in silico molecular docking studies were also carried out for the inhibition of cyclooxygenase-II enzyme. These molecular docking results were well complemented to the antioxidant activity studies.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-017-1834-9