Genus   human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study

Objective To investigate the association between genus β human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population. Design Population based case-control study. Setting New Hampshire, USA. Participants 2366 skin cancer cases and controls from the general popula...

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Bibliographic Details
Published in:BMJ 2010-07, Vol.341 (jul08 1), p.c2986-c2986
Main Authors: Karagas, Margaret R, Waterboer, Tim, Li, Zhongze, Nelson, Heather H, Michael, Kristina M, Bavinck, Jan Nico Bouwes, Perry, Ann E, Spencer, Steven K, Daling, Janet, Green, Adele C, Pawlita, Michael
Format: Article
Language:English
Subjects:
Antibodies
Basal cell carcinoma
Biomarkers
Cancer therapies
Epidemiology
Glucocorticoids
Health risk assessment
Human papillomavirus
Immunosuppression
Interviews
Laboratories
Medical research
Melanoma
Papillomaviridae
Population
Population studies
Population-based studies
Proteins
Serology
Skin cancer
Squamous cell carcinoma
Sun
Sunburn & sun tanning
Transplants & implants
Ultraviolet radiation
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Summary:Objective To investigate the association between genus β human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population. Design Population based case-control study. Setting New Hampshire, USA. Participants 2366 skin cancer cases and controls from the general population aged 25 to 74 years (663 squamous cell carcinoma, 898 basal cell carcinoma, 805 controls), with plasma samples tested for L1 antibodies to 16 genus β human papillomaviruses by multiplex serology. Main outcome measures Odds ratios for squamous cell carcinoma and basal cell carcinoma associated with seropositivity to β human papillomaviruses. Results Squamous cell carcinoma, but not basal cell carcinoma, cases had a higher prevalence of each of the individual β human papillomaviruses assayed compared with controls. The odds ratios for squamous cell carcinoma increased with the number of β types positive (odds ratio for one type positive 0.99 (95% confidence interval 0.74 to 1.33); two to three types positive 1.44 (1.03 to 2.01); four to eight types positive 1.51 (1.03 to 2.20); more than eight types positive 1.71 (1.12 to 2.62); P for trend (categorical)
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.c2986