Characterization of NFATc1/Smad3 complexes in pancreatic cancer

During carcinogenesis, cells often acquire inactivating mutations in the Smad4 gene, decreasing the tumor suppressive functions of TGFβ signaling in favor of oncogenic properties. The involvement of AP-1 proteins in NFATc1/Smad3 transcription complex assembly suggests pharmacological intervention wi...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-07, Vol.17 (3), p.S29-S29
Main Authors: Hasselluhn, Marie Christin, Bohnenberger, Hanibal, Lenz, Christof, Strack, Astrid, Johnsen, Steven, Ellenrieder, Volker, Hessmann, Elisabeth
Format: Article
Language:English
Subjects:
Endocrinology & Metabolism
Gastroenterology and Hepatology
Pancreatic cancer
Smad3 protein
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Summary:During carcinogenesis, cells often acquire inactivating mutations in the Smad4 gene, decreasing the tumor suppressive functions of TGFβ signaling in favor of oncogenic properties. The involvement of AP-1 proteins in NFATc1/Smad3 transcription complex assembly suggests pharmacological intervention with signaling pathways upstream of AP-1 as a beneficial approach to tackle Smad4-deficient...
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2017.05.092