A comprehensive prognostic signature based on interaction of immune cell infiltration with stromal composition for resected pancreatic ductal adenocarcinoma

Aims: We investigated whether infiltration of immune cell subsets affect the survival of pancreatic cancer patients and affect stromal composition (fibrogenic (aSMA high/collagen-I high); fibrolytic stroma (aSMA high/collagen-I low). All statistical tests were two-sided and performed in R. Results:...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2017-07, Vol.17 (3), p.S34-S34
Main Authors: Mahajan, Ujjwal Mukund, Langhoff, Enno, Costello, Eithne, Greenhalf, William, Halloran, Christopher, Beyer, Georg, Weiss, Frank Ulrich, Neoptolemos, John P, Büchler, Markus W, Kohlmann, Thomas, Lerch, Markus M, Mayerle, Julia
Format: Article
Language:English
Subjects:
Adenocarcinoma
Collagen
Endocrinology & Metabolism
Gastroenterology and Hepatology
Medical prognosis
Pancreas
Pancreatic cancer
T cell receptors
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Summary:Aims: We investigated whether infiltration of immune cell subsets affect the survival of pancreatic cancer patients and affect stromal composition (fibrogenic (aSMA high/collagen-I high); fibrolytic stroma (aSMA high/collagen-I low). All statistical tests were two-sided and performed in R. Results: In 1824 TMA from 382 patients (94.6%) immune cell composition was...
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2017.05.107