A cross-reacting material CRM197conjugate vaccine induces diphtheria toxin neutralizing antibody response in children and adolescents infected or not with HIV

Anti-diphtheria antibody levels decrease with aging, and frequent booster vaccinations are required to maintain herd immunity. We analyzed the diphtheria toxin neutralizing antibody (DT-Nab) response induced by a conjugate vaccine (meningococcal C polysaccharide-CRM197) in HIV-vertically infected (H...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2017-07, Vol.35 (31), p.3803
Main Authors: Silva, Giselle P, Santos, Rafaela S, Pereira-Manfro, Wânia F, Ferreira, Bianca, Barreto, Daniella M, Frota, Ana Cristina C, Hofer, Cristina B, Milagres, Lucimar G
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anti-diphtheria antibody levels decrease with aging, and frequent booster vaccinations are required to maintain herd immunity. We analyzed the diphtheria toxin neutralizing antibody (DT-Nab) response induced by a conjugate vaccine (meningococcal C polysaccharide-CRM197) in HIV-vertically infected (HI) children and adolescents and healthy controls (HC) with matched age. We report the association of DT-Nab with the bactericidal antibodies to serogroup C meningococcus (MenC). Before vaccination, 21 HI patients (50%) had no protection against diphtheria (=0.1IU/ml). About half of the HC (56%) had complete protection before immunization and 6 subjects (12%) had no protection against diphtheria. After one and two vaccine injections, 96% of HC and 64% of HI vaccinees, respectively, showed full protection against diphtheria. These data indicate that CRM197was able to induce primary and/or booster response in both groups of individuals.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.05.080