Pathologic Duodenogastric Reflux and Inhibited Gastric Acid Secretion as Potential Factors Decreasing Omeprazole Stability

Pathologic duodenogastric reflux (PDGR) with high-amplitude changes in gastric pH can lead to destruction of the coating layer, resulting in degradation of the active compounds due to decrease in pH level after a reflux. According to our self-developed formula, pH 7 exposure time of resistance to PD...

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e66-e67
Main Authors: Serebrova, S.Y, Kurguzova, D.O, Prokofiev, A.B, Krasnikh, L.M, Vasilenko, G.F, Zhuravleva, M.V, Svistunov, A.A, Smolyarchuk, E.A, Barkov, A.O
Format: Article
Language:English
Subjects:
Degradation
Destruction
Hydrogen ions
Internal Medicine
Medical Education
Omeprazole
pH effects
Secretion
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Summary:Pathologic duodenogastric reflux (PDGR) with high-amplitude changes in gastric pH can lead to destruction of the coating layer, resulting in degradation of the active compounds due to decrease in pH level after a reflux. According to our self-developed formula, pH 7 exposure time of resistance to PDGR for omeprazole is 4 minutes, i.e. the active substance should not be released within 4 minutes at pH 7.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.204