Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of Icure Donepezil Patch in Healthy Male Volunteers

Methods PK data used in this analysis were from 60 Korean, healthy, male subjects in two Phase 1 studies, where all the subjects received single or multiple doses of donepezil patch of 43.75, 87.5, and 175 mg, and 12 of them received single oral dose of donepezil, 10 mg followed...

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e55-e55
Main Authors: Yoon, S. Kyu, Bae, K.-S, Hong, D, Kim, S. Su, Shim, Y. Ho, Choi, Y. Kweon, Lim, H.-S
Format: Article
Language:English
Subjects:
Computer simulation
Data processing
Donepezil
Internal Medicine
Medical Education
Pharmacodynamics
Pharmacokinetics
Pharmacology
Simulation
Simulation analysis
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Description
Summary:Methods PK data used in this analysis were from 60 Korean, healthy, male subjects in two Phase 1 studies, where all the subjects received single or multiple doses of donepezil patch of 43.75, 87.5, and 175 mg, and 12 of them received single oral dose of donepezil, 10 mg followed...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.171