Nicotine Metabolite Ratio in Smokers: A Real World Experience

Background The ratio of two metabolites derived from nicotine smoking, 3’-hydroxycotinine (3HC) and cotinine (COT) (nicotine metabolite ratio, NMR), reflects the activity of the liver enzyme CYP2A6 and it has been shown to predict response to smoking cessation drugs in clinical trials. Methods We ca...

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e87-e87
Main Authors: Fogli, S, Polini, B, Carrozzi, L, Pistelli, F, Puppo, G, Palla, A, Saba, A, Zucchi, R, Re, M. Del, Danesi, R
Format: Article
Language:English
Subjects:
Clinical trials
Cotinine
Drug addiction
Drugs
Internal Medicine
Liver
Medical Education
Medical research
Metabolites
Nicotine
NMR
Nuclear magnetic resonance
Smoking
Smoking cessation
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Summary:Background The ratio of two metabolites derived from nicotine smoking, 3’-hydroxycotinine (3HC) and cotinine (COT) (nicotine metabolite ratio, NMR), reflects the activity of the liver enzyme CYP2A6 and it has been shown to predict response to smoking cessation drugs in clinical trials. Methods We carried out a clinical validation of...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.271