Pharmacokinetic and Pharmacodynamic Modeling and Simulation Analysis of CTB-001, Recently Developed Bivalirudin

Methods PK/PD data used for this analysis were from a randomized, double-blind, placebo-controlled, single-dose, dose escalation phase 1 studies for 33 healthy, Korean, male subjects (NCT01647893), where 8 subjects including 2 with placebo in each of the first 3 dose groups (0.375 (group I), 0.75 (g...

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e54-e54
Main Authors: Han, S, Choi, H. Youn, Kim, Y. Han, Kim, W. Joo, Bae, K.-S, Lim, H.-S
Format: Article
Language:English
Subjects:
Computer simulation
Data processing
Internal Medicine
Medical Education
Pharmacodynamics
Pharmacokinetics
Pharmacology
Simulation analysis
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Summary:Methods PK/PD data used for this analysis were from a randomized, double-blind, placebo-controlled, single-dose, dose escalation phase 1 studies for 33 healthy, Korean, male subjects (NCT01647893), where 8 subjects including 2 with placebo in each of the first 3 dose groups (0.375 (group I), 0.75 (group II), 1.5 mg/kg (group...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.169