ABCB1 C3435T Polymorphism Affects In Different Ways The Pharmacokinetics of Antipsychotics and Antidepressants

Background P-glycoprotein, encoded by ABCB1 gene, is an ATP-dependent drug efflux pump which exports substances outside the cell. Study was approved by local research ethics committee and all subjects signed an informed consent.

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e36-e36
Main Authors: Saiz-Rodríguez, M, Belmonte, C, Cabaleiro, T, López-Rodríguez, R, Román, M, Ochoa, D, Talegón, M, Abad-Santos, F
Format: Article
Language:English
Subjects:
Antidepressants
Antipsychotics
Efflux
Ethics
Exports
Glycoproteins
Informed consent
Internal Medicine
Medical Education
P-Glycoprotein
Pharmacokinetics
Pharmacology
Polymorphism
Psychotropic drugs
Research ethics
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Description
Summary:Background P-glycoprotein, encoded by ABCB1 gene, is an ATP-dependent drug efflux pump which exports substances outside the cell. Study was approved by local research ethics committee and all subjects signed an informed consent.
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.111