Analysis of Pharmacokinetic Interaction Between Amiodarone/Desethylamiodarone and Metoprolol

Methods We analyzed retrospectively 69 serum concentrations of AM, DEA, M and OH-M measured by HPLC method with UV or fluorescent detection from 29 patients (years 2014-2015). The results indicate that important drug-drug interaction between metoprolol and amiodaron is due to inhibition of CYP2D6, m...

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e84-e84
Main Authors: Hrudikova-Vyskocilova, E, Kacirova, I, Duricova, J, Urinovska, R, Grundmann, M
Format: Article
Language:English
Subjects:
Amiodarone
CYP2D6 protein
Cytochrome P450
Drug dosages
Drug interaction
Drug interactions
Fluorescence
High-performance liquid chromatography
Internal Medicine
Liquid chromatography
Medical Education
Metabolism
Metabolites
Metoprolol
Pharmacokinetics
Pharmacology
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Summary:Methods We analyzed retrospectively 69 serum concentrations of AM, DEA, M and OH-M measured by HPLC method with UV or fluorescent detection from 29 patients (years 2014-2015). The results indicate that important drug-drug interaction between metoprolol and amiodaron is due to inhibition of CYP2D6, mainly by DEA. [...]wen the combination...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.261