Methanolic Extracts of Corchorus olitorius (L.) and Adansonia digitata (L.) Leaves Against Irradiation-Induced Atherosclerosis in Male Wistar Rats

The present study investigated the anti-atherosclerotic and antioxidative effect of the methanolic extracts (MExt) of Corchorus olitorius (CO) and Adansonia digitata (AD) leaves on irradiation-induced atherosclerosis in male Wistar rats. Atherosclerosis was induced in male rats by a single dose of 6...

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Bibliographic Details
Published in:Notulae scientia biologicae 2017-04, Vol.9 (2)
Main Authors: BELLO, Kabir O, NWOZO, Sarah O, Johnson, OLADELE, MUSTAPHA, Kabir K, QUADRI, Lukman A
Format: Article
Language:English
Subjects:
Adansonia digitata
Antioxidants
Arteriosclerosis
Atherosclerosis
Catalase
Cochorous olitorius
Dosage
Enzymes
Flavonoids
Gamma rays
Glutathione
Glutathione peroxidase
Irradiation
Leaves
Lipids
Liver
Lovastatin
Malondialdehyde
Peroxidase
Polyphenols
Rats
Saponins
Side effects
Superoxide dismutase
Tannins
γ Radiation
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Summary:The present study investigated the anti-atherosclerotic and antioxidative effect of the methanolic extracts (MExt) of Corchorus olitorius (CO) and Adansonia digitata (AD) leaves on irradiation-induced atherosclerosis in male Wistar rats. Atherosclerosis was induced in male rats by a single dose of 6 gray whole body gamma radiation. MExt of C. olitorious and A. digitata leaves at 500 and 1,000 mg/kg bwt were administered as treatment for 7 days. Blood serum was analysed for lipid profile, MDA (malondialdehyde) and liver tissue for antioxidants enzymes, whereas the therapeutic potential was compared to the lipids-lowering drug lovastatin at 10 mg/kg/bwt. The phytochemical studies showed the presence of polyphenols, flavonoids, tannins and saponins. Treatment with MExt of CO and AD normalized the elevated MDA level, whereas the activities of superoxide dismutase, catalase and glutathione peroxidase in the treated rats increased. Pronounced changes were observed at 1,000 mg/kg bwt mixture of MExt of CO and AD for 1 weeks and it was more potent than the standard drug. The current study provided strong evidence that MExt of CO and AD might be important in the treatment of atherosclerosis and ROS without any side effects at the studied dosage and duration.
ISSN:2067-3205
2067-3264
DOI:10.15835/nsb9210046