Nitrobenzoxadiazole derivatives as nitric oxide donors: ESR study using spin trapping

The ability of nitrobenzoxadiazoles to induce the SOX-operon from a genetically engineered biosensor based on E. coli MG 1655 (pSoxS-lux) was confirmed by the fact of producing nitric oxide. The NO-donating properties of three nitrobenzoxadiazole derivatives bearing π-excessive carbo- and heterocycl...

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Bibliographic Details
Published in:Russian chemical bulletin 2017, Vol.66 (1), p.76-82
Main Authors: Serezhenkov, V. A., Tkachev, N. A., Semenyuk, Yu. P., Kurbatov, S. V., Kharchenko, E. Yu, Chistyakov, V. A.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Derivatives
E coli
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Genetic engineering
Inorganic Chemistry
Nitric oxide
Organic Chemistry
Sodium sulfide
Trapping
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Summary:The ability of nitrobenzoxadiazoles to induce the SOX-operon from a genetically engineered biosensor based on E. coli MG 1655 (pSoxS-lux) was confirmed by the fact of producing nitric oxide. The NO-donating properties of three nitrobenzoxadiazole derivatives bearing π-excessive carbo- and heterocycles were found by the ESR method using spin trapping. The yield of nitrogen(II) oxide was 17, 0.3, and 1.6%. Sodium sulfide accelerates the thiol-dependent transformation and increases the yield of nitric oxide to 27, 16, and 12%, respectively.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-017-1702-2