A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride leading to primary arylamines

A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride was achieved in DMF in the presence of 10 mol% of an MCM-41-immobilised L-proline-copper(I) complex (MCM-41-L-proline-CuI) with Cs2CO3 as base, yielding a variety of primary arylamines i...

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Bibliographic Details
Published in:Journal of chemical research 2017-06, Vol.41 (6), p.315-320
Main Authors: Huang, Xue, Xiao, Ruian, You, Chongren, Yan, Tao, Cai, Mingzhong
Format: Article
Language:English
Subjects:
Amines
Aromatic compounds
Cascade chemical reactions
Coordination compounds
Copper
Filtration
Iodides
Organic compounds
Proline
Reagents
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Summary:A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride was achieved in DMF in the presence of 10 mol% of an MCM-41-immobilised L-proline-copper(I) complex (MCM-41-L-proline-CuI) with Cs2CO3 as base, yielding a variety of primary arylamines in good to excellent yields. The new heterogeneous copper complex can be easily prepared from commercially readily available and inexpensive reagents, recovered by a simple filtration of the reaction solution and used at least seven more times without any decrease in activity.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751917X14931195075580