Modifier-assisted differential mobility–tandem mass spectrometry method for detection and quantification of amphetamine-type stimulants in urine

An advantage of differential mobility spectrometry (DMS) is it provides an orthogonal mechanism to mass spectrometry (MS). The DMS-MS/MS detects analytes in the gas phase on the basis of differences in ion mobility in low and high electric fields, which makes DMS-MS/MS an alternative to chromatograp...

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Bibliographic Details
Published in:Analytica chimica acta 2016-11, Vol.946, p.1-8
Main Authors: Chen, Pai-Shan, Chen, Shu-Hua, Chen, Jung-Hsuan, Haung, Wan-Yun, Liu, Hsin-Tung, Kong, Po-Hsin, Yang, Olivia Hsu-Yuan
Format: Article
Language:English
Subjects:
Amphetamine - chemistry
Amphetamine - isolation & purification
Amphetamine - urine
Amphetamine-type stimulants
Amphetamines
Argon
Carbon dioxide
Carrier density
Carrier gases
Central Nervous System Stimulants - chemistry
Central Nervous System Stimulants - isolation & purification
Central Nervous System Stimulants - urine
Chromatography, Liquid
Differential mobility spectrometry
Drug of abuse
Electric fields
Gases
Helium
Humans
Ionic mobility
Ions
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Methanol
Methanol - chemistry
Mobility
Nitrogen
Nitrogen - chemistry
Quality control
Quantitation
Rare gases
Scientific imaging
Sensitivity
Separation
Stimulants
Tandem Mass Spectrometry - methods
Temperature
Temperature effects
Test procedures
Urinalysis - methods
Urine
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Summary:An advantage of differential mobility spectrometry (DMS) is it provides an orthogonal mechanism to mass spectrometry (MS). The DMS-MS/MS detects analytes in the gas phase on the basis of differences in ion mobility in low and high electric fields, which makes DMS-MS/MS an alternative to chromatographic separation-MS. One drawback of DMS is its limited resolution and sensitivity, especially for detecting small molecules when using a nonpolar inert gas as the carrier gas. The present work has evaluated the effects on peak capacity of adding chemical modifiers to inert carrier gases (nitrogen, helium, argon and carbon dioxide). Use of a methanol-helium mixture gave improvements in both separation and sensitivity. Nine structurally similar amphetamine-type stimulants were determined in urine without pretreatment of the samples before analysis. After optimization of carrier gas, nature and concentration of chemical modifier, and DMS temperature, limits of detection ranging from 1.1 to 2.7 ng mL−1, with a linear range of three orders of magnitude (5–5000 ng mL−1) were achieved. Precision was
ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2016.09.027