Role of Herbal Drugs in Nephrotoxicity and Neurological Disorder: Connecting a Bridge between Kidney and Brain

Chronic kidney disease is associated with a number of other factors that have been proposed as mediators of cognitive impairment, including anemia, increased levels of inflammatory cytokines, oxidative stress, and alterations in lipid and homocysteine metabolism2, 3. Impaired kidney function is asso...

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Bibliographic Details
Published in:Asian Journal of Research in Chemistry 2013-10, Vol.6 (10), p.1165
Main Authors: Dutta, Deepika, Harikumar, S L, Grewal, Amarjot Kaur
Format: Article
Language:English
Subjects:
Albinism
Alzheimer's disease
Antioxidants
Brain
Bridges
Cognitive ability
Cognitive enhancement
Cytokines
Dementia
Diabetes
Diabetic neuropathy
Drugs
Enzymes
Herbal medicine
Kidney diseases
Lipid peroxidation
Lipids
Liver
Memory
Oxidative stress
Pharmaceuticals
Rodents
Studies
Tumor necrosis factor-TNF
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Summary:Chronic kidney disease is associated with a number of other factors that have been proposed as mediators of cognitive impairment, including anemia, increased levels of inflammatory cytokines, oxidative stress, and alterations in lipid and homocysteine metabolism2, 3. Impaired kidney function is associated with a more rapidly decline in cognitive, especially in semantic memory, episodic memory, and working memory. Curcumin treatment also increased the glutathione content and glutathione peroxidase activity of kidney tissues in adriamycin rats. While in brain curcumin modulates the inflammatory response by down-regulating the activity of cyclooxygenase-2 (COX-2), lipoxygenase, and inducible nitric oxide synthase (iNOS) enzymes; inhibits the production of the inflammatory cytokines tumor necrosis factor-alpha (TNF-a), interleukin (IL) -1, -2, -6, -8, and - 127'8' Curcuminoids as a mixture is pharmacologically different form of purified curcumin. Curcuminoids mixture is known to inhibit lipid peroxidation in rat brain homogenates, scavenge nitric oxide radicals, protect cells from Aß(1-42) insults, inhibit Aß induced inflammatory cytokines expression, enhance memory and inhibit in-vitro beta amyloid fibril formation in addition to its strong AChE inhibitory activity. 2. Kidney of mice ingested to lead plus Coriandrum sativum extracts shows the tubules appear more or less normal. [...]coriander extract produced protective effects in renal tissue against lead toxicity11. The results from various studies showed that administration of C. sativum aqueous extract improved memory deficits induced by scopolamine injection and exhibited higher inhibition of lipid peroxidation when compared with ascorbic acid in both rat liver and brain in rats. Protective role of coriandrum sativum (coriander) extracts...
ISSN:0974-4169
0974-4150