RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN LOCALLY ADVANCED BREAST CANCER ACCORDING TO TUMOR SUBTYPES

The aim of neo adjuvant chemotherapy is to downstage the tumor load to increase the rate of breast-conserving surgery and to gain information on in-vivo drug response. Gene expression profiling studies have shown that breast cancer is heterogeneous disease, consisting of subtypes with different mole...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2017-06 (3), p.407
Main Authors: Tabassum, Sobia, Zahid, Naila
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Analysis
Biopsy
Breast cancer
Cancer research
Cancer therapies
Chemotherapy
Epidermal growth factor
Gene expression
Lymphatic system
Mastectomy
Medical prognosis
Metastasis
Surgery
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Summary:The aim of neo adjuvant chemotherapy is to downstage the tumor load to increase the rate of breast-conserving surgery and to gain information on in-vivo drug response. Gene expression profiling studies have shown that breast cancer is heterogeneous disease, consisting of subtypes with different molecular features and clinical outcomes5. [...]it is important to identify factors associated with the presence or absence of PCR after preoperative chemotherapy. Clinicopathologic characteristics such as clinical TNM stage (tumor, node, metastasis), age at diagnosis, estrogen receptor (ER) status, histological grade; have been associated with PCR after neoadjuvant chemotherapy6,7. Studies have identified four major subtypes of breast cancer according to immunohistochemistry these are, (1) luminal A, (ER+ve and/or PR+ve, Human Epidermal Growth Factor Receptor 2 (HER 2)-ve, Ki-67 14%) OR, HER2+ve with any Ki-67) (3) Her2 over expressed (ER-ve, PR-ve, and HER2+ve) and (4) Triple negative (ER-ve, PR-ve, and HER2-ve)9-12. Initial tumour size and axillary lymph node status were assessed on clinical examination by measuring scale. Predictive role of molecular subtypes in response to neoadjuvant chemotherapy in breast cancer patients in northeast china. "Molecular Subtypes and Tumor Response to Neoadjuvant Chemotherapy in Patients with locally advanced breast cancer. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. "Breast cancer subtyping by immunohistochemistry and histological grade outperforms breast cancer intrinsic subtypes in predicting neoadjuvant chemotherapy response," Breast Cancer Research and Treatment 2013; 140(1): 63-71.
ISSN:0030-9648
2411-8842