Effects of current treatments in progressive retinal nerve fiber layer loss in multiple sclerosis patients

Purpose To evaluate progressive changes in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS) to assess the possible neuroprotective role of different frequently used therapies in this disease. Methods 104 patients with MS underwent a complete ophthalmic evaluation includi...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2016-10, Vol.94 (S256), p.n/a
Main Authors: Satue, M., Rodrigo, M.J., Obis, J., Cipres Alastuey, M., Vilades, E., Garcia‐Martin, E.
Format: Article
Language:English
Subjects:
Copolymer 1
Interferon
Monoclonal antibodies
Multiple sclerosis
Neurodegeneration
Neuroprotection
Ophthalmology
Optical Coherence Tomography
Patients
Retina
Thinning
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Summary:Purpose To evaluate progressive changes in the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS) to assess the possible neuroprotective role of different frequently used therapies in this disease. Methods 104 patients with MS underwent a complete ophthalmic evaluation including structural assessment of the RNFL thickness using Spectral domain Optical coherence tomography (SD‐OCT). All subjects were re‐evaluated after 5 years to quantify structural changes. Changes were compared between treated and untreated patients, between different therapies and between intramuscular (IM) interferon (IFN) beta‐1a (Avonex) and other frequently prescribed treatments (subcutaneus IFN beta‐1a, IFN beta‐1b, glatiramer acetate, metoxantrone and natalizumab). Results Significant thinning of the peripapillary RNFL thickness was observed at 5‐year follow‐up in all patients (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2016.0349