Novel biocompatible glucose-based deep eutectic solvent as recyclable medium and promoter for expedient multicomponent green synthesis of diverse three and four substituted pyrazole-4-carbonitrile derivatives

A novel biocompatible glucose-based deep eutectic solvent (DES) is reported for the first time in the multicomponent synthesis of diverse three and four substituted pyrazole-4-carbonitrile derivatives under catalyst-free condition without using any harmful organic solvent even for purification of th...

Full description

Saved in:
Bibliographic Details
Published in:Research on chemical intermediates 2017-08, Vol.43 (8), p.4731-4744
Main Authors: Aryan, Reza, Beyzaei, Hamid, Nojavan, Masoomeh, Rezaei, Meysam
Format: Article
Language:English
Subjects:
Aldehydes
Biocompatibility
Catalysis
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Derivatives
Eutectic reactions
Eutectic temperature
Glucose
Hydrogen bonding
Inorganic Chemistry
Malononitrile
Physical Chemistry
Promotion
Pyrazole
Solvents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel biocompatible glucose-based deep eutectic solvent (DES) is reported for the first time in the multicomponent synthesis of diverse three and four substituted pyrazole-4-carbonitrile derivatives under catalyst-free condition without using any harmful organic solvent even for purification of the products. The desired products were obtained with high degree of diversity from the reaction of malononitrile, aromatic aldehydes and various hydrazine derivatives as nitrogen source at room temperature within short reaction times and good to excellent product yields. The deep eutectic solvent was also recycled and reused at least four times with only a slight loss of efficiency. A plausible mechanism was also proposed indicating the role of DES hydrogen bonding in the reaction promotion.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-017-2908-5