One‐pot Synthesis of 3‐phenyl‐4‐pyrazolylmethylene‐isoxazol‐(5H)‐ones Catalyzed by Sodium Benzoate in Aqueous Media under the Influence of Ultrasound Waves: A Green Chemistry Approach

A series of 4‐pyrazolylmethylene‐3‐phenylisoxazol‐5(4H)‐ones have been prepared from Knoevenagel condensation of pyrazole‐4‐carbaxaldehyde with isoxazolone precursors or via one‐pot three‐component cyclocondensation of pyrazole‐4‐carbaxaldehyde with β‐ketoesters and hydroxylamine hydrochloride in th...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2017-07, Vol.54 (4), p.2483-2492
Main Authors: Konkala, Veera Swamy, Dubey, Pramod Kumar
Format: Article
Language:English
Subjects:
Catalysis
Catalysts
Catalytic activity
Chemical synthesis
Condensation
Green development
Pyrazole
Reaction time
Sodium
Sodium benzoate
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Summary:A series of 4‐pyrazolylmethylene‐3‐phenylisoxazol‐5(4H)‐ones have been prepared from Knoevenagel condensation of pyrazole‐4‐carbaxaldehyde with isoxazolone precursors or via one‐pot three‐component cyclocondensation of pyrazole‐4‐carbaxaldehyde with β‐ketoesters and hydroxylamine hydrochloride in the presence of sodium benzoate in water under the influence of ultrasonic waves. The merits of this method are efficient, clean, green, easy work‐up, high yields, and shorter reaction time, and the catalyst could be recycled easily without affecting the catalytic activity.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.2848