Bacteria can proliferate in thawed cryoprecipitate stored at room temperature for longer than 4ￂ h

Although key coagulation factor activities are maintained in thawed cryoprecipitate stored for up to 24 h at ambient temperature, several jurisdictions limit such storage to 4-6 h. Here, we separately spiked thawed cryoprecipitate units with four bacterial strains: Staphylococcus epidermidis,Serrati...

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Bibliographic Details
Published in:Vox sanguinis 2017-07, Vol.112 (5), p.477
Main Authors: Ramirez-Arcos, S, Jenkins, C, Sheffield, W P
Format: Article
Language:English
Subjects:
Ambient temperature
Bacteria
Coagulation
Deactivation
Inactivation
Pathogens
Pseudomonas aeruginosa
Pseudomonas putida
Room temperature
Staphylococcus epidermidis
Storage
Strains (organisms)
Temperature effects
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Summary:Although key coagulation factor activities are maintained in thawed cryoprecipitate stored for up to 24 h at ambient temperature, several jurisdictions limit such storage to 4-6 h. Here, we separately spiked thawed cryoprecipitate units with four bacterial strains: Staphylococcus epidermidis,Serratia liquefaciens,Pseudomonas putida and Pseudomonas aeruginosa. No strains grew in the first 4 h of storage, but by 24 h, three of four exhibited up to 1000-fold proliferation. Pathogen inactivation technologies could be explored to mitigate the safety risk posed by extending storage of thawed cryoprecipitate at room temperature.
ISSN:0042-9007
1423-0410
DOI:10.1111/vox.12517