Bacteria can proliferate in thawed cryoprecipitate stored at room temperature for longer than 4ￂ h

Although key coagulation factor activities are maintained in thawed cryoprecipitate stored for up to 24 h at ambient temperature, several jurisdictions limit such storage to 4-6 h. Here, we separately spiked thawed cryoprecipitate units with four bacterial strains: Staphylococcus epidermidis,Serrati...

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Published in:Vox sanguinis 2017-07, Vol.112 (5), p.477
Main Authors: Ramirez-Arcos, S, Jenkins, C, Sheffield, W P
Format: Article
Language:English
Subjects:
Ambient temperature
Bacteria
Coagulation
Deactivation
Inactivation
Pathogens
Pseudomonas aeruginosa
Pseudomonas putida
Room temperature
Staphylococcus epidermidis
Storage
Strains (organisms)
Temperature effects
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Jenkins, C
Sheffield, W P
description Although key coagulation factor activities are maintained in thawed cryoprecipitate stored for up to 24 h at ambient temperature, several jurisdictions limit such storage to 4-6 h. Here, we separately spiked thawed cryoprecipitate units with four bacterial strains: Staphylococcus epidermidis,Serratia liquefaciens,Pseudomonas putida and Pseudomonas aeruginosa. No strains grew in the first 4 h of storage, but by 24 h, three of four exhibited up to 1000-fold proliferation. Pathogen inactivation technologies could be explored to mitigate the safety risk posed by extending storage of thawed cryoprecipitate at room temperature.
doi_str_mv 10.1111/vox.12517
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subjects Ambient temperature
Bacteria
Coagulation
Deactivation
Inactivation
Pathogens
Pseudomonas aeruginosa
Pseudomonas putida
Room temperature
Staphylococcus epidermidis
Storage
Strains (organisms)
Temperature effects
title Bacteria can proliferate in thawed cryoprecipitate stored at room temperature for longer than 4ￂ h
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