Meso‐Functionalization of Silk Fibroin by Upconversion Fluorescence and Near Infrared In Vivo Biosensing

In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso‐functionalization is present...

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Bibliographic Details
Published in:Advanced functional materials 2017-07, Vol.27 (26), p.n/a
Main Authors: Song, Yang, Lin, Zaifu, Kong, Lingqing, Xing, Yao, Lin, Naibo, Zhang, Zhisen, Chen, Bing‐Hung, Liu, Xiang‐Yang
Format: Article
Language:English
Subjects:
Assembly
bioimaging
Biomedical materials
Carbonyl groups
Carbonyls
Fluorescence
hierarchical structures
Hydroxyl groups
Materials science
Medical imaging
Mice
Near infrared radiation
Polyethylene glycol
Polyethylenes
Scaffolds
Silicon dioxide
silk
Silk fibroin
Surgical implants
Tracking devices
Upconversion
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Summary:In biomedical applications, it is very desirable to monitor the in vivo state of implanted devices, i.e., tracking the location, the state, and the interaction between the implanted devices and cell tissues. To achieve this goal, a generic strategy of soft materials meso‐functionalization is presented. This is to acquire silk fibroin (SF) materials with added functions, i.e., in vivo bioimaging/sensing. The functionalization is by 3D materials assembly of functional components, lanthanide(Ln)‐doped upconversion nanoparticles (UCNPs) on the mesoscopic scale to acquire upconversion fluorescent emission. To implement the meso‐functionalization, the surfaces of UCNPs are modified by the hydroxyl groups (OH) from SiO2 or polyethylene glycol coating layers, which can interact with the carbonyl groups (CO) in SF scaffolds. The functionalized silk scaffolds are further implanted subcutaneously into mice, which allows the silk scaffolds to have fluorescent in vivo bioimaging and other biomedical functions. This material functionalization strategy may lead to the rational design of biomaterials in a more generic way. Bioimaging for silk fibroin scaffolds is achieved by the incorporation of surface‐modified upconversion nanoparticles into the mesoscopic structure of silk fibroin materials via mesoscopic materials assembly. This allows real‐time, non‐invasive imaging in vivo.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201700628