A Biocatalytic Route to Highly Enantioenriched [beta]-Hydroxydioxinones

A novel biocatalytic system to access a wide variety of [beta]-hydroxydioxinones from [beta]-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds c...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2017-04, Vol.359 (7), p.1131
Main Authors: Betori, Rick C, Miller, Eric R, Scheidt, Karl A
Format: Article
Language:English
Subjects:
Scaffolds
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Summary:A novel biocatalytic system to access a wide variety of [beta]-hydroxydioxinones from [beta]-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in [beta]-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201700095