Synthesis of Fluoromethyl‐Substituted Isoxazolines via Transition Metal‐Free Oxyfluorination of Alkenyl Oximes

A mild and efficient transition metal‐free intramolecular oxyfluorination of alkenyl oximes is demonstrated. The reaction tolerates a range of substrates to give a series of monofluoromethylated isoxazoline derivatives with good yields. The possible pathways are proposed based on the reaction result...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2017-05, Vol.359 (10), p.1626-1630
Main Authors: Zhao, Juan, Jiang, Min, Liu, Jin‐Tao
Format: Article
Language:English
Subjects:
alkenyl oximes
intramolecular reaction
isoxazolines
Oximes
oxyfluorination
Substrates
transition metal-free conditions
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Summary:A mild and efficient transition metal‐free intramolecular oxyfluorination of alkenyl oximes is demonstrated. The reaction tolerates a range of substrates to give a series of monofluoromethylated isoxazoline derivatives with good yields. The possible pathways are proposed based on the reaction results and control experiments.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201601405