Antibody and cytokine levels in humans fed on by the common bedbug, Cimex lectularius L

Summary Little is known about cimicosis, the resultant dermal reaction from feeding activity by the common bedbug, Cimex lectularius L. We fed C. lectularius on human study subjects four times over four weeks and measured serum cytokine and antibody levels, and subjects recorded any cimicosis. The a...

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Bibliographic Details
Published in:Parasite immunology 2017-03, Vol.39 (3), p.n/a
Main Authors: Sheele, J. M., Ridge, G. E., Coppolino, K., Bonfield, T., Young, A. B., Gaines, S. L., McCormick, T. S.
Format: Article
Language:English
Subjects:
Animals
Antibodies - blood
Antibodies - immunology
antibody
bedbug
Bedbugs - immunology
Cimex lectularius
cimicosis
cytokine
Cytokines
Cytokines - blood
Feeding
Female
Humans
immunoglobulin
Immunoglobulin E
Immunoglobulin G
Immunoglobulin G - blood
Insect Bites and Stings - blood
Insect Bites and Stings - immunology
Interleukin 1
Interleukin 10
Interleukin 4
Interleukin 5
Interleukin 6
Male
Skin
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Summary:Summary Little is known about cimicosis, the resultant dermal reaction from feeding activity by the common bedbug, Cimex lectularius L. We fed C. lectularius on human study subjects four times over four weeks and measured serum cytokine and antibody levels, and subjects recorded any cimicosis. The average time for subjects to develop cimicosis decreased with each feeding from 8.4, to 2.1, 1.5 and 1.3 days, respectively. There were no significant changes in total IgG, IgG1, IgG2, IgG4 or IgE levels between the first and fourth bedbug feedings, but there was a significant decrease in total IgG3 levels (P
ISSN:0141-9838
1365-3024
DOI:10.1111/pim.12411