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Histological Diagnoses of Military Personnel Undergoing Lung Biopsy After Deployment to Southwest Asia
Introduction The current understanding of associations between lung disease and military deployment to Southwest Asia, including Iraq and Afghanistan, is both controversial and limited. We sought to clarify the relation between military deployment and biopsy-proven lung disease. Methods Retrospectiv...
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| Published in: | Lung 2017-08, Vol.195 (4), p.507-515 |
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| container_end_page | 515 |
| container_issue | 4 |
| container_start_page | 507 |
| container_title | Lung |
| container_volume | 195 |
| creator | Madar, Cristian S. Lewin-Smith, Michael R. Franks, Teri J. Harley, Russell A. Klaric, John S. Morris, Michael J. |
| description | Introduction
The current understanding of associations between lung disease and military deployment to Southwest Asia, including Iraq and Afghanistan, is both controversial and limited. We sought to clarify the relation between military deployment and biopsy-proven lung disease.
Methods
Retrospective data were analyzed for military personnel with non-neoplastic lung biopsies evaluated at the Armed Forces Institute of Pathology or Joint Pathology Center (January 2005 to December 2012).
Results
Of 391 subjects, 137 (35.0%) had deployed to Southwest Asia prior to biopsy. Compared to non-deployed subjects, those deployed were younger (median age 37 vs. 51 years) with higher representation of African Americans (30.0 vs. 16.9%). Deployed patients were more likely diagnosed with non-necrotizing granulomas (OR 2.4). Non-deployed subjects had higher frequency of idiopathic interstitial pneumonias, particularly organizing pneumonia. Prevalence of small airways diseases including constrictive bronchiolitis was low.
Conclusions
This study provides a broader understanding of diversity of biopsy-proven non-neoplastic lung disease as it relates to military deployment to Southwest Asia and importantly did not show an increased prevalence of small airway disease to include constrictive bronchiolitis. |
| doi_str_mv | 10.1007/s00408-017-0009-2 |
| format | article |
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The current understanding of associations between lung disease and military deployment to Southwest Asia, including Iraq and Afghanistan, is both controversial and limited. We sought to clarify the relation between military deployment and biopsy-proven lung disease.
Methods
Retrospective data were analyzed for military personnel with non-neoplastic lung biopsies evaluated at the Armed Forces Institute of Pathology or Joint Pathology Center (January 2005 to December 2012).
Results
Of 391 subjects, 137 (35.0%) had deployed to Southwest Asia prior to biopsy. Compared to non-deployed subjects, those deployed were younger (median age 37 vs. 51 years) with higher representation of African Americans (30.0 vs. 16.9%). Deployed patients were more likely diagnosed with non-necrotizing granulomas (OR 2.4). Non-deployed subjects had higher frequency of idiopathic interstitial pneumonias, particularly organizing pneumonia. Prevalence of small airways diseases including constrictive bronchiolitis was low.
Conclusions
This study provides a broader understanding of diversity of biopsy-proven non-neoplastic lung disease as it relates to military deployment to Southwest Asia and importantly did not show an increased prevalence of small airway disease to include constrictive bronchiolitis.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-017-0009-2</identifier><identifier>PMID: 28536739</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Adult ; African Americans ; Age ; Armed forces ; Biopsy ; Bronchiolitis Obliterans - ethnology ; Bronchiolitis Obliterans - pathology ; Bronchopneumonia ; Chi-Square Distribution ; Constrictions ; Data processing ; European Continental Ancestry Group ; Female ; Granuloma, Respiratory Tract - ethnology ; Granuloma, Respiratory Tract - pathology ; Humans ; Idiopathic Interstitial Pneumonias - ethnology ; Idiopathic Interstitial Pneumonias - pathology ; Logistic Models ; Lung - pathology ; Lung diseases ; Lung Diseases - ethnology ; Lung Diseases - pathology ; Male ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Middle East ; Military ; Military deployment ; Military Personnel ; Minority & ethnic groups ; Multivariate Analysis ; Obstructive lung disease ; Odds Ratio ; Pathology ; Patients ; Pneumology/Respiratory System ; Pneumonia ; Predictive Value of Tests ; Prevalence ; Respiratory tract diseases ; Retrospective Studies ; Risk Factors ; United States - epidemiology ; Young Adult</subject><ispartof>Lung, 2017-08, Vol.195 (4), p.507-515</ispartof><rights>Springer Science+Business Media New York (outside the USA) 2017</rights><rights>Lung is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-32d28654777091c0afe168856fe60a9466a458bf483a1eb4b418729248deb20c3</citedby><cites>FETCH-LOGICAL-c372t-32d28654777091c0afe168856fe60a9466a458bf483a1eb4b418729248deb20c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28536739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madar, Cristian S.</creatorcontrib><creatorcontrib>Lewin-Smith, Michael R.</creatorcontrib><creatorcontrib>Franks, Teri J.</creatorcontrib><creatorcontrib>Harley, Russell A.</creatorcontrib><creatorcontrib>Klaric, John S.</creatorcontrib><creatorcontrib>Morris, Michael J.</creatorcontrib><title>Histological Diagnoses of Military Personnel Undergoing Lung Biopsy After Deployment to Southwest Asia</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Introduction
The current understanding of associations between lung disease and military deployment to Southwest Asia, including Iraq and Afghanistan, is both controversial and limited. We sought to clarify the relation between military deployment and biopsy-proven lung disease.
Methods
Retrospective data were analyzed for military personnel with non-neoplastic lung biopsies evaluated at the Armed Forces Institute of Pathology or Joint Pathology Center (January 2005 to December 2012).
Results
Of 391 subjects, 137 (35.0%) had deployed to Southwest Asia prior to biopsy. Compared to non-deployed subjects, those deployed were younger (median age 37 vs. 51 years) with higher representation of African Americans (30.0 vs. 16.9%). Deployed patients were more likely diagnosed with non-necrotizing granulomas (OR 2.4). Non-deployed subjects had higher frequency of idiopathic interstitial pneumonias, particularly organizing pneumonia. Prevalence of small airways diseases including constrictive bronchiolitis was low.
Conclusions
This study provides a broader understanding of diversity of biopsy-proven non-neoplastic lung disease as it relates to military deployment to Southwest Asia and importantly did not show an increased prevalence of small airway disease to include constrictive bronchiolitis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African Americans</subject><subject>Age</subject><subject>Armed forces</subject><subject>Biopsy</subject><subject>Bronchiolitis Obliterans - ethnology</subject><subject>Bronchiolitis Obliterans - pathology</subject><subject>Bronchopneumonia</subject><subject>Chi-Square Distribution</subject><subject>Constrictions</subject><subject>Data processing</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Granuloma, Respiratory Tract - ethnology</subject><subject>Granuloma, Respiratory Tract - pathology</subject><subject>Humans</subject><subject>Idiopathic Interstitial Pneumonias - ethnology</subject><subject>Idiopathic Interstitial Pneumonias - pathology</subject><subject>Logistic Models</subject><subject>Lung - pathology</subject><subject>Lung diseases</subject><subject>Lung Diseases - ethnology</subject><subject>Lung Diseases - pathology</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Middle East</subject><subject>Military</subject><subject>Military deployment</subject><subject>Military Personnel</subject><subject>Minority & ethnic groups</subject><subject>Multivariate Analysis</subject><subject>Obstructive lung disease</subject><subject>Odds Ratio</subject><subject>Pathology</subject><subject>Patients</subject><subject>Pneumology/Respiratory System</subject><subject>Pneumonia</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Respiratory tract diseases</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>United States - epidemiology</subject><subject>Young Adult</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kEFLwzAYhoMobk5_gBcJeK5-SdMkPc5NnTBR0J1D2qU1o2tm0iL792ZsihcvXw7f870veRC6JHBDAMRtAGAgEyAiAYA8oUdoSFhKEyIyOEZDSBlJaGQG6CyEFUSQk-wUDajMUi7SfIiqmQ2da1xtS93gqdV164IJ2FX42Ta2036LX40Prm1Ngxft0vja2bbG8z6OO-s2YYvHVWc8nppN47Zr03a4c_jN9d3HlwkdHgerz9FJpZtgLg7vCC0e7t8ns2T-8vg0Gc-TMhW0S1K6pJJnTAgBOSlBV4ZwKTNeGQ46Z5xrlsmiYjLVxBSsYEQKmlMml6agUKYjdL3P3Xj32cd2tXK9b2OlIjmllGecQaTIniq9C8GbSm28XcevKgJqZ1btzaooTO3MKhpvrg7JfbE2y9-LH5URoHsgxFVbG_-n-t_Ub0lzgxo</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Madar, Cristian S.</creator><creator>Lewin-Smith, Michael R.</creator><creator>Franks, Teri J.</creator><creator>Harley, Russell A.</creator><creator>Klaric, John S.</creator><creator>Morris, Michael J.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170801</creationdate><title>Histological Diagnoses of Military Personnel Undergoing Lung Biopsy After Deployment to Southwest Asia</title><author>Madar, Cristian S. ; Lewin-Smith, Michael R. ; Franks, Teri J. ; Harley, Russell A. ; Klaric, John S. ; Morris, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-32d28654777091c0afe168856fe60a9466a458bf483a1eb4b418729248deb20c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African Americans</topic><topic>Age</topic><topic>Armed forces</topic><topic>Biopsy</topic><topic>Bronchiolitis Obliterans - ethnology</topic><topic>Bronchiolitis Obliterans - pathology</topic><topic>Bronchopneumonia</topic><topic>Chi-Square Distribution</topic><topic>Constrictions</topic><topic>Data processing</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Granuloma, Respiratory Tract - ethnology</topic><topic>Granuloma, Respiratory Tract - pathology</topic><topic>Humans</topic><topic>Idiopathic Interstitial Pneumonias - ethnology</topic><topic>Idiopathic Interstitial Pneumonias - pathology</topic><topic>Logistic Models</topic><topic>Lung - pathology</topic><topic>Lung diseases</topic><topic>Lung Diseases - ethnology</topic><topic>Lung Diseases - pathology</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Middle East</topic><topic>Military</topic><topic>Military deployment</topic><topic>Military Personnel</topic><topic>Minority & ethnic groups</topic><topic>Multivariate Analysis</topic><topic>Obstructive lung disease</topic><topic>Odds Ratio</topic><topic>Pathology</topic><topic>Patients</topic><topic>Pneumology/Respiratory System</topic><topic>Pneumonia</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Respiratory tract diseases</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>United States - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madar, Cristian S.</creatorcontrib><creatorcontrib>Lewin-Smith, Michael R.</creatorcontrib><creatorcontrib>Franks, Teri J.</creatorcontrib><creatorcontrib>Harley, Russell A.</creatorcontrib><creatorcontrib>Klaric, John S.</creatorcontrib><creatorcontrib>Morris, Michael J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madar, Cristian S.</au><au>Lewin-Smith, Michael R.</au><au>Franks, Teri J.</au><au>Harley, Russell A.</au><au>Klaric, John S.</au><au>Morris, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological Diagnoses of Military Personnel Undergoing Lung Biopsy After Deployment to Southwest Asia</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>195</volume><issue>4</issue><spage>507</spage><epage>515</epage><pages>507-515</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><abstract>Introduction
The current understanding of associations between lung disease and military deployment to Southwest Asia, including Iraq and Afghanistan, is both controversial and limited. We sought to clarify the relation between military deployment and biopsy-proven lung disease.
Methods
Retrospective data were analyzed for military personnel with non-neoplastic lung biopsies evaluated at the Armed Forces Institute of Pathology or Joint Pathology Center (January 2005 to December 2012).
Results
Of 391 subjects, 137 (35.0%) had deployed to Southwest Asia prior to biopsy. Compared to non-deployed subjects, those deployed were younger (median age 37 vs. 51 years) with higher representation of African Americans (30.0 vs. 16.9%). Deployed patients were more likely diagnosed with non-necrotizing granulomas (OR 2.4). Non-deployed subjects had higher frequency of idiopathic interstitial pneumonias, particularly organizing pneumonia. Prevalence of small airways diseases including constrictive bronchiolitis was low.
Conclusions
This study provides a broader understanding of diversity of biopsy-proven non-neoplastic lung disease as it relates to military deployment to Southwest Asia and importantly did not show an increased prevalence of small airway disease to include constrictive bronchiolitis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28536739</pmid><doi>10.1007/s00408-017-0009-2</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult African Americans Age Armed forces Biopsy Bronchiolitis Obliterans - ethnology Bronchiolitis Obliterans - pathology Bronchopneumonia Chi-Square Distribution Constrictions Data processing European Continental Ancestry Group Female Granuloma, Respiratory Tract - ethnology Granuloma, Respiratory Tract - pathology Humans Idiopathic Interstitial Pneumonias - ethnology Idiopathic Interstitial Pneumonias - pathology Logistic Models Lung - pathology Lung diseases Lung Diseases - ethnology Lung Diseases - pathology Male Medical diagnosis Medicine Medicine & Public Health Middle Aged Middle East Military Military deployment Military Personnel Minority & ethnic groups Multivariate Analysis Obstructive lung disease Odds Ratio Pathology Patients Pneumology/Respiratory System Pneumonia Predictive Value of Tests Prevalence Respiratory tract diseases Retrospective Studies Risk Factors United States - epidemiology Young Adult |
| title | Histological Diagnoses of Military Personnel Undergoing Lung Biopsy After Deployment to Southwest Asia |
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