Front Cover: Chemoenzymatic Synthesis of Triazololactams Structurally Related to Pancratistatin (Eur. J. Org. Chem. 27/2017)

The cover picture shows amaryllidaceae alkaloids, which are well‐known because of their toxicity and potential medical use. Among them, the narciclasine group and particularly fully oxygenated pancratistatin are promising anticancer agents but the complexity of the molecular structure undermines the...

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Bibliographic Details
Published in:European journal of organic chemistry 2017-07, Vol.2017 (27), p.3896-3896
Main Authors: de la Sovera, Victoria, Suescun, Leopoldo, Bellomo, Ana, Gonzalez, David
Format: Article
Language:English
Subjects:
Alkaloids
Anticancer properties
Catalysis
Chemical synthesis
Complexity
Group dynamics
Molecular structure
Toxicity
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Summary:The cover picture shows amaryllidaceae alkaloids, which are well‐known because of their toxicity and potential medical use. Among them, the narciclasine group and particularly fully oxygenated pancratistatin are promising anticancer agents but the complexity of the molecular structure undermines the development of drugs. Efficient synthetic approaches developed by the Hudlicky group during the last 25 years allowed us to prepare drug‐like molecules that structurally resemble alkaloids with the pancratistatin skeleton by enzymatic catalysis and click chemistry. The original alkaloids and their synthetic analogues are depicted over a Narcissus flower blooming in The Hague last March. Details are discussed in the Communication by D. Gonzalez et al. on page 3912 ff (https://doi.org/10.1002/ejoc.201700334).
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201700918