C21 OMICS IN LUNG DISEASE: Human Small Airway-On-A-Chip: A Novel Microphysiological System To Model Lung Inflammation, Accelerate Drug Development And Enable Inhalational Toxico-Analysis

Importantly, by connecting the small airway chip to a custom-designed electromechanical instrument that 'breathes' whole cigarette smoke in and out of the chip microchannels, we successfully recreated smoke-induced oxidative stress, identified new ciliary micropathologies, and discovered u...

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Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Benam, K, Novak, R, Villenave, R, Lucchesi, C, Hubeau, C, Nawroth, J, Hirano-Kobayashi, M, Ferrante, T C, Choe, Y, Prantil-Baun, R, Weaver, J C, Hamilton, G A, Bahinski, A, Parker, K K, Ingber, D E
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Language:English
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Chronic obstructive pulmonary disease
Cytokines
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container_title American journal of respiratory and critical care medicine
container_volume 195
creator Benam, K
Novak, R
Villenave, R
Lucchesi, C
Hubeau, C
Nawroth, J
Hirano-Kobayashi, M
Ferrante, T C
Choe, Y
Prantil-Baun, R
Weaver, J C
Hamilton, G A
Bahinski, A
Parker, K K
Ingber, D E
description Importantly, by connecting the small airway chip to a custom-designed electromechanical instrument that 'breathes' whole cigarette smoke in and out of the chip microchannels, we successfully recreated smoke-induced oxidative stress, identified new ciliary micropathologies, and discovered unique COPD-specific molecular signatures. [...]this platform revealed a subtle ciliary damage triggered by acute exposure to electronic cigarette. [...]the human small airway-on-a-chip offers a powerful complement to animal models for studying human lung pathophysiology.
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source Freely Accessible Science Journals; EZB-FREE-00999 freely available EZB journals
subjects Chronic obstructive pulmonary disease
Cytokines
title C21 OMICS IN LUNG DISEASE: Human Small Airway-On-A-Chip: A Novel Microphysiological System To Model Lung Inflammation, Accelerate Drug Development And Enable Inhalational Toxico-Analysis
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