D96 INFECTIOUSNESS AND TRANSMISSION OF TUBERCULOSIS: Outcomes, Infectiousness And Transmission Dynamics Of Patients With Extensively Drug Resistant Tuberculosis And Home-Discharged Patients With Programmatically Incurable Tb: A Prospective Cohort Study

For patients from the Western Cape transmission dynamics, infectiousness, and drug susceptibility were interrogated using whole genome sequencing (WGS), a cough aerosol sampling system (CASS), and phenotypic testing for 18 drugs, respectively. Findings: Overall, 203/273 (74%) XDR-TB patients had pro...

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Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Limberis, J D, Pietersen, E, Phelan, J, Esmail, A, Lesosky, M, Fennelly, K P, Riele, J Te, Mastrapa, B, Spiller, P, Streicher, E M, Dolby, T, Abdallah, A M, Rached, F Ben, Simpson, J, Smith, L, Gumbo, T, Van Helden, P, Sirgel, F A, McNerney, R, Theron, G, Pain, A, Clark, T G, Warren, R M, Dheda, K U J
Format: Article
Language:English
Subjects:
Tuberculosis
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Summary:For patients from the Western Cape transmission dynamics, infectiousness, and drug susceptibility were interrogated using whole genome sequencing (WGS), a cough aerosol sampling system (CASS), and phenotypic testing for 18 drugs, respectively. Findings: Overall, 203/273 (74%) XDR-TB patients had programmatically incurable TB and unfavorable outcomes of either treatment failure, relapse, default, or death despite treatment with a capreomycin and para-aminosalicylic-acid-based regimen. 172/273 (63%) of patients were home-discharged with 104/172 (60%) of these having an unfavourable outcome. 54/172 (31%) were treatment failures and their median post-discharge time to death was 9-9 months (IQR 4-2-17-4).
ISSN:1073-449X
1535-4970