C32 LUNG INJURY, ARDS, AND SEPSIS: Optimization Of A Protocol For Quantification Of The Innate Immune Response In Human Whole Blood

In order to better define the inter-individual genetic and environmental determinants of innate immunity, it is important to establish robust, reproducible, and high-throughput methods for quantifying TLR pathway output that are applicable to accessible primary human cells/tissues. In studies curren...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Ajayi, T A, Gabor, K, Rai, P, Fessler, M B
Format: Article
Language:English
Subjects:
Blood & organ donations
Cytokines
Sepsis
Online Access:Get full text
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Summary:In order to better define the inter-individual genetic and environmental determinants of innate immunity, it is important to establish robust, reproducible, and high-throughput methods for quantifying TLR pathway output that are applicable to accessible primary human cells/tissues. In studies currently underway, we are using these conditions to compare the innate immune response of blood donors with defined single nucleotide polymorphisms in the gene immunity-related GTPase M (IRGM) that have been reported to associate with increased risk for Crohn's Disease and Tuberculosis.
ISSN:1073-449X
1535-4970