A96 BEST OF PEDIATRICS: Lung Hypoplasia In A Genetic Mouse Model Of Down Syndrome

Rationale: Infants and children with Down syndrome (DS) are at high risk for developing lung hypoplasia and pulmonary hypertension that contributes to cardiorespiratory morbidity and mortality. Genetic mouse models for DS containing mouse orthologues for human chromosome 21 are distributed across th...

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Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Bush, D, Minic, A, Seedorf, G, Dodson, B, Shepherd, D P, Abman, S H, Galambos, C
Format: Article
Language:English
Subjects:
Chromosomes
Down syndrome
Hypoxia
Lungs
Pediatrics
Rodents
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container_title American journal of respiratory and critical care medicine
container_volume 195
creator Bush, D
Minic, A
Seedorf, G
Dodson, B
Shepherd, D P
Abman, S H
Galambos, C
description Rationale: Infants and children with Down syndrome (DS) are at high risk for developing lung hypoplasia and pulmonary hypertension that contributes to cardiorespiratory morbidity and mortality. Genetic mouse models for DS containing mouse orthologues for human chromosome 21 are distributed across three murine chromosomes, including chromosome 10 (encodes ES) and 16 (encodes RCAN1).
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source Freely Accessible Journals; EZB Free E-Journals
subjects Chromosomes
Down syndrome
Hypoxia
Lungs
Pediatrics
Rodents
title A96 BEST OF PEDIATRICS: Lung Hypoplasia In A Genetic Mouse Model Of Down Syndrome
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