C93 HOST DEFENSE AGAINST PATHOGEN INVASION: Hepcidin-Mediated Iron Sequestration Is Required For Host Defense Against Gram-Negative Pneumonia

[...]short-term treatment with a synthetic hepcidin analogue restored hypoferremia in hepcidin-deficient hosts and mediated improved bacterial control and improved outcome. Conclusions: Hepcidin expression is induced during Klebsiella pneumonia, mediates reduction of plasma iron, and is required for...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Michels, K, Zhang, Z, Bettina, A, Cagnina, R E, Stefanova, D, Burdick, M, Nemeth, E, Ganz, T, Mehrad, B
Format: Article
Language:English
Subjects:
Infections
Plasma
Pneumonia
Rodents
Online Access:Get full text
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Summary:[...]short-term treatment with a synthetic hepcidin analogue restored hypoferremia in hepcidin-deficient hosts and mediated improved bacterial control and improved outcome. Conclusions: Hepcidin expression is induced during Klebsiella pneumonia, mediates reduction of plasma iron, and is required for control of bacterial growth.
ISSN:1073-449X
1535-4970