A28 EXOSOMES AND MICRORNA: P53 And Microrna-34a Feedback Promotes Lung Epithelial Injury And Remodeling

Alveolar epithelial cell (AEC) apoptosis, accumulation of myofibroblasts and extracellular matrix deposition results in progressive loss of lung function in IPF. AECS were isolated from mouse models of bleomycin (BLM), silica, cigarette smoke (CS) and sepsis induced lung injury.

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Shetty, S K, Tiwari, N, Marudamuthu, A, Puthusseri, B, Bhandary, Y P, Fu, J, Levin, J, Idell, S, Shetty, S
Format: Article
Language:English
Subjects:
Apoptosis
Lungs
MicroRNAs
Pulmonary fibrosis
Rodents
Sepsis
Online Access:Get full text
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Description
Summary:Alveolar epithelial cell (AEC) apoptosis, accumulation of myofibroblasts and extracellular matrix deposition results in progressive loss of lung function in IPF. AECS were isolated from mouse models of bleomycin (BLM), silica, cigarette smoke (CS) and sepsis induced lung injury.
ISSN:1073-449X
1535-4970