D27 I WANNA BE YOUR ... NOVEL MECHANISTIC INSIGHT INTO PULMONARY VASCULAR DISEASE: Loss Of Wnt5a Disrupts Endothelial-Pericyte Interactions In Pulmonary Arterial Hypertension

A novel conditional endothelial specific Wnt5a knockout ( Wnt5aEC/EC) mouse model was generated to assess impact of Wnt5a deficiency on hypoxia induced pulmonary hypertension. Results: Characterization of Wnt/PCP gene expression in healthy PMVECs and pericytes alone and in co-culture revealed that P...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Yuan, K, Shamskhou, E, Discipulo, M, Orcholski, M, Honda, H, Reddy, S, Perez, V De Jesus
Format: Article
Language:English
Subjects:
Gene expression
Hypoxia
Pulmonary hypertension
Rodents
Online Access:Get full text
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Summary:A novel conditional endothelial specific Wnt5a knockout ( Wnt5aEC/EC) mouse model was generated to assess impact of Wnt5a deficiency on hypoxia induced pulmonary hypertension. Results: Characterization of Wnt/PCP gene expression in healthy PMVECs and pericytes alone and in co-culture revealed that PMVECs produced Wnt5a (a Wnt ligand) only when these cells are in close proximity.
ISSN:1073-449X
1535-4970