D21 IMMUNE PATHWAYS IN ACUTE LUNG INJURY AND FIBROSIS: Surfactant Protein-D Regulates The Inflammatory Response And Modulates The Transcription Factor Profile Of Group 2 Innate Lymphoid Cells In The Lung After Ozone Inhalation

[...]with C57BL/6 mice, Balb/c mice had a heightened ozone-induced neutrophil count in the BAL associated with increased IL-25 (an ILC2 activating cytokine), Bclllb, RORa, and GATA3 mRNA (ILC2 transcription factors) in the lung. CONCLUSIONS: Because ILC3 but not ILC2 are known to produce IL-17A, a c...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Flayer, C H, Ge, M Q, Kovacs, P B, Ott, S, Killingbeck, S S, Haczku, A
Format: Article
Language:English
Subjects:
Cytokines
Gene expression
Neutrophils
Surfactants
Transcription factors
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Summary:[...]with C57BL/6 mice, Balb/c mice had a heightened ozone-induced neutrophil count in the BAL associated with increased IL-25 (an ILC2 activating cytokine), Bclllb, RORa, and GATA3 mRNA (ILC2 transcription factors) in the lung. CONCLUSIONS: Because ILC3 but not ILC2 are known to produce IL-17A, a cytokine with neutrophil promoting capabilities, we speculate that ILC2 become functionally plastic and act like ILC3 during ozone-induced inflammation.
ISSN:1073-449X
1535-4970