C109 NEW TECHNOLOGY IN SLEEP: DIAGNOSTICS AND THERAPEUTICS: Effects Of One Month Of Nightly Zopiclone On Obstructive Sleep Apnea Severity And Symptoms: A Randomized, Double-Blind, Placebo-Controlled Trial

[...]this study aimed to determine the effects of 1 month of nightly zopiclone on OSA severity and measures of sleepiness and alertness in OSA patients who have low to moderate respiratory arousal thresholds and mild overnight hypoxaemia (ACTRN12613001106729). Methods: Screening polysomnography (PSG...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Carter, S G, Carberry, J C, Cho, G, Fisher, L P, Rollo, C P, Stevens, D, D'Rozario, A L, McKenzie, D K, Grunstein, R R, Eckert, D J
Format: Article
Language:English
Subjects:
Insomnia
Medical diagnosis
Sleep apnea
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Summary:[...]this study aimed to determine the effects of 1 month of nightly zopiclone on OSA severity and measures of sleepiness and alertness in OSA patients who have low to moderate respiratory arousal thresholds and mild overnight hypoxaemia (ACTRN12613001106729). Methods: Screening polysomnography (PSG) quantified the respiratory arousal threshold (nadir epiglottic pressure just prior to arousal) and nadir arterial blood oxygen saturation (SaO2) in 69 individuals. 30 eligible OSA patients (apnea/hypopnea index [AHI] =22.4+11.3 events/h sleep) with a low to moderate respiratory arousal threshold (0 to -25cmH2O) and mild overnight hypoxemia (nadir SaO2>75 %) then underwent PSG on three occasions at baseline, night 1 and night 30.
ISSN:1073-449X
1535-4970